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Published by Jove Publications Inc, 1979
ISBN 10: 0515048704ISBN 13: 9780515048704
Seller: HPB Inc., Dallas, TX, U.S.A.
Book
mass_market. Condition: Very Good. Connecting readers with great books since 1972! Used books may not include companion materials, and may have some shelf wear or limited writing. We ship orders daily and Customer Service is our top priority!.
Published by A Jove Book, 1979
ISBN 10: 0515048704ISBN 13: 9780515048704
Seller: HPB-Emerald, Dallas, TX, U.S.A.
Book
paperback. Condition: Good. Connecting readers with great books since 1972! Used books may not include companion materials, and may have some shelf wear or limited writing. We ship orders daily and Customer Service is our top priority!.
Published by Jove Publications Inc, 1979
ISBN 10: 0515048704ISBN 13: 9780515048704
Seller: HPB-Movies, Dallas, TX, U.S.A.
Book
mass_market. Condition: Good. Connecting readers with great books since 1972! Used books may not include companion materials, and may have some shelf wear or limited writing. We ship orders daily and Customer Service is our top priority!.
Published by Jove Publications Inc, 1979
ISBN 10: 0515048704ISBN 13: 9780515048704
Seller: ThriftBooks-Dallas, Dallas, TX, U.S.A.
Book
Mass Market Paperback. Condition: Fair. No Jacket. Readable copy. Pages may have considerable notes/highlighting. ~ ThriftBooks: Read More, Spend Less 0.45.
Published by A Jove Book January 1979, 1979
ISBN 10: 0515048704ISBN 13: 9780515048704
Seller: R Bookmark, Youngtown, AZ, U.S.A.
Book
Mass Market Paperback. Condition: Used - Acceptable. Book twisting from being on shelf.
Published by A Jove Book January 1979, 1979
ISBN 10: 0515048704ISBN 13: 9780515048704
Seller: R Bookmark, Youngtown, AZ, U.S.A.
Book
Mass Market Paperback. Condition: Used - Acceptable. Shelf and spine wear -- reader's copy. Pages yellowing from age.
Mass Market Paperback. Condition: Very Good. First Edition. [1st printing] July 1979. Cover art by David Schleinkofer. Paperback original. A little creasing, edgewear and minor scuffs.
Published by Jove/HBJ, New York, NY, U.S.A., 1979
Seller: Stuart W. Wells III, Norwalk, CT, U.S.A.
Book First Edition
Mass Market Paperback. Condition: Fine. First Edition. Publisher's Code M4870. As new, never read.
Paperback. first edition. , near fine, unread, , new looking, , paperback,
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523ISBN 13: 9783838120522
Seller: Lucky's Textbooks, Dallas, TX, U.S.A.
Book
Condition: New.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523ISBN 13: 9783838120522
Seller: PBShop.store US, Wood Dale, IL, U.S.A.
Book Print on Demand
PAP. Condition: New. New Book. Shipped from UK. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523ISBN 13: 9783838120522
Seller: Ria Christie Collections, Uxbridge, United Kingdom
Book Print on Demand
Condition: New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
Published by Sudwestdeutscher Verlag fur Hochschulschrifte 2011-12, 2011
ISBN 10: 3838120523ISBN 13: 9783838120522
Seller: Chiron Media, Wallingford, United Kingdom
Book
PF. Condition: New.
Published by Jove Publications Inc, 1979
ISBN 10: 0515048704ISBN 13: 9780515048704
Seller: BennettBooksLtd, North Las Vegas, NV, U.S.A.
Book
Condition: New. New. In shrink wrap. Looks like an interesting title! 0.5.
Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG Jul 2015, 2015
ISBN 10: 3838120523ISBN 13: 9783838120522
Seller: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germany
Book Print on Demand
Taschenbuch. Condition: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -While investigating the involvement of REV3, the catalytic subunit of TLS Polymerase zeta (Pol zeta) in the development of chemotherapy resistance, it was found that inhibition of REV3 expression per se suppresses colony formation of cancer cells whereas normal cells were less affected. It was confirmed that inhibition of REV3 in various cancer cell lines leads to a growth inhibition, due to accumulation of persistent DNA damage, subsequently leading to the activation of the ATM-dependent DNA damage response (DDR) cascade. Inhibition of REV3 in p53-proficient cancer cells results in a G1-arrest and senescence. In contrast, the inhibition of REV3 in p53-deficient or p53-knockout cancer cells results in a growth inhibition and a G2/M-arrest whereas a small fraction of the p53-deficient or p53-knockout cancer cells can overcome the G2/M-arrest, which results in mitotic slippage and aneuploidy. It is shown for the first time that inhibition of a TLS Pol confers synthetic sickness/lethality specifically in cancer cells. The inhibition REV3 per se suppresses cancer cell growth whereas normal cells are less affected, thus identifying REV3 as a potential target for a cancer-specific therapy. 92 pp. Englisch.
Published by Südwestdeutscher Verlag Für Hochschulschriften AG Co. KG, 2011
ISBN 10: 3838120523ISBN 13: 9783838120522
Seller: AHA-BUCH GmbH, Einbeck, Germany
Book Print on Demand
Taschenbuch. Condition: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - While investigating the involvement of REV3, the catalytic subunit of TLS Polymerase zeta (Pol zeta) in the development of chemotherapy resistance, it was found that inhibition of REV3 expression per se suppresses colony formation of cancer cells whereas normal cells were less affected. It was confirmed that inhibition of REV3 in various cancer cell lines leads to a growth inhibition, due to accumulation of persistent DNA damage, subsequently leading to the activation of the ATM-dependent DNA damage response (DDR) cascade. Inhibition of REV3 in p53-proficient cancer cells results in a G1-arrest and senescence. In contrast, the inhibition of REV3 in p53-deficient or p53-knockout cancer cells results in a growth inhibition and a G2/M-arrest whereas a small fraction of the p53-deficient or p53-knockout cancer cells can overcome the G2/M-arrest, which results in mitotic slippage and aneuploidy. It is shown for the first time that inhibition of a TLS Pol confers synthetic sickness/lethality specifically in cancer cells. The inhibition REV3 per se suppresses cancer cell growth whereas normal cells are less affected, thus identifying REV3 as a potential target for a cancer-specific therapy.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523ISBN 13: 9783838120522
Seller: PBShop.store UK, Fairford, GLOS, United Kingdom
Book Print on Demand
PAP. Condition: New. New Book. Delivered from our UK warehouse in 4 to 14 business days. THIS BOOK IS PRINTED ON DEMAND. Established seller since 2000.
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523ISBN 13: 9783838120522
Seller: moluna, Greven, Germany
Book Print on Demand
Condition: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Knobel Philip AlexanderDissertation and study of Biology at the University of Zurich, Switzerland. Postdoctoral fellow at the Institute for Research in Biomedicine in Barcelona, Spain.While investigating the involvement of REV3, .
Published by Südwestdeutscher Verlag für Hochschulschriften, 2011
ISBN 10: 3838120523ISBN 13: 9783838120522
Seller: Mispah books, Redhill, SURRE, United Kingdom
Book
Paperback. Condition: Like New. Like New. book.